Mitchell B Cohen Selected Research

guanylin

9/2013	Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen.
1/2013	Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis.
1/2011	Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier.
9/2005	Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model.
12/2002	Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation.

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Mitchell B Cohen Research Topics

Disease

6	Infections 04/2022 - 06/2002
6	Cholera 04/2022 - 04/2002
4	Constipation 12/2021 - 05/2010
4	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 12/2021 - 05/2010
4	Diarrhea 01/2015 - 04/2002
3	Inflammation (Inflammations) 09/2013 - 06/2011
3	Eosinophilic Esophagitis 11/2006 - 02/2006
2	Lymphadenopathy 02/2015 - 02/2007
2	Gaucher Disease (Gaucher's Disease) 02/2015 - 02/2007
2	Clostridium Infections 01/2014 - 09/2013
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2011 - 04/2009
2	Neoplasms (Cancer) 03/2011 - 09/2005
2	Cystic Fibrosis (Mucoviscidosis) 05/2008 - 10/2003
2	Adenoma (Adenomas) 11/2007 - 12/2002
2	Eosinophilia 11/2006 - 02/2006
1	Gliosis 02/2015
1	Lung Diseases (Lung Disease) 02/2015
1	Glucose Intolerance 11/2014
1	Body Weight (Weight, Body) 11/2014
1	Obesity 11/2014
1	Abdominal Pain (Pain, Abdominal) 12/2013
1	Hypersensitivity (Allergy) 12/2013
1	Colitis 01/2013
1	Hyperammonemia 08/2012
1	Ornithine Carbamoyltransferase Deficiency Disease 08/2012
1	Intestinal Failure 12/2011
1	Sepsis (Septicemia) 12/2011
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 09/2011
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 03/2011
1	Carcinogenesis 01/2011
1	Protein-Losing Enteropathies (Protein-Losing Enteropathy) 02/2007
1	Mastocytosis 02/2006
1	Disease Susceptibility (Diathesis) 02/2006
1	Herpes Zoster 12/2005
1	Polyps 09/2005
1	Steatorrhea 12/2003

Drug/Important Bio-Agent (IBA)

6	VaccinesIBA 04/2022 - 04/2002
6	Guanylate Cyclase (Guanylyl Cyclase)IBA 12/2021 - 03/2011
5	guanylinIBA 09/2013 - 12/2002
4	uroguanylinIBA 11/2014 - 09/2005
3	AcidsIBA 09/2013 - 06/2002
3	Proteins (Proteins, Gene)FDA Link 01/2013 - 12/2005
2	Biomarkers (Surrogate Marker)IBA 04/2022 - 11/2006
2	Cholera ToxinIBA 11/2018 - 01/2015
2	cholera vaccine CVD 103-HgRIBA 11/2018 - 01/2016
2	Cholera Vaccines FDA Link 11/2018 - 04/2002
2	AntigensIBA 11/2018 - 01/2015
2	linaclotideIBA 12/2013 - 05/2010
2	LigandsIBA 09/2013 - 06/2011
2	CytokinesIBA 09/2013 - 01/2013
2	Messenger RNA (mRNA)IBA 01/2013 - 02/2006
2	Anti-Bacterial Agents (Antibiotics)IBA 05/2011 - 04/2009
2	Peptides (Polypeptides)IBA 03/2011 - 05/2010
2	Enterotoxin ReceptorsIBA 01/2011 - 09/2005
2	ChloridesIBA 11/2007 - 10/2003
2	Chemokine CCL26IBA 11/2006 - 02/2006
1	Attenuated VaccinesIBA 11/2018
1	AntibodiesIBA 11/2018
1	LipopolysaccharidesIBA 11/2018
1	UbiquitinIBA 02/2015
1	prouroguanylinIBA 11/2014
1	GuanosineIBA 12/2013
1	ChemokinesIBA 09/2013
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013
1	InterleukinsIBA 01/2013
1	Ornithine Carbamoyltransferase (Ornithine Transcarbamylase)IBA 08/2012
1	Urea (Carbamide)FDA LinkGeneric 08/2012
1	Bicarbonates (Hydrogen Carbonate)IBA 05/2008
1	AnionsIBA 11/2007
1	Eosinophil-Derived NeurotoxinIBA 11/2006
1	Fluticasone (Cutivate)FDA LinkGeneric 11/2006
1	Claudin-1IBA 12/2005
1	Interleukin-8 (Interleukin 8)IBA 12/2005
1	ActininIBA 12/2005
1	NF-kappa B (NF-kB)IBA 12/2005
1	Claudin-4IBA 12/2005
1	Enterotoxins (Enterotoxin)IBA 09/2005
1	Fatty Acids (Saturated Fatty Acids)IBA 12/2003
1	DysprosiumIBA 10/2003
1	Triglycerides (Triacylglycerol)IBA 10/2003
1	heat stable toxin (E coli)IBA 12/2002
1	SecretagoguesIBA 12/2002
1	Peru 15IBA 04/2002

Therapy/Procedure

2	Enzyme Therapy 02/2015 - 02/2007
2	Therapeutics 02/2015 - 09/2011
1	Fecal Microbiota Transplantation 01/2014
1	Aftercare (After-Treatment) 12/2011
1	Central Venous Catheters 12/2011
1	Enzyme Replacement Therapy 02/2007